5-氮雜-2′-脫氧胞苷

5-氮雜-2′-脫氧胞苷

性質(zhì)

Related Categories AN-AZ, Approved Therapeutics/Drug Candidates,Bioactive Small Molecule Alphabetical Index, Eisai,Fluorination Ready Pharma-Developed Compounds,
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InChI Key   XAUDJQYHKZQPEU-KVQBGUIXSA-N
assay   ≥97%
solubility   acetic acid: water (1:1): 50 mg/mL
originator   Eisai

產(chǎn)品描述

包裝

5, 10 mg in glass bottle

50 mg in glass insert

Application

5-Aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, DNA and promoter region of p16 gene.[3][4][5][6]

Biochem/physiol Actions

5′-脫氧雜氮胞苷可引起DNA去甲基化或半去甲基化。DNA去甲基化可通過(guò)隨著提高的核酸酶活性而“打開(kāi)”染色質(zhì)的結(jié)構(gòu)來(lái)調(diào)控基因的表達(dá)。這種染色質(zhì)結(jié)構(gòu)的重塑可實(shí)現(xiàn)轉(zhuǎn)錄因子與啟動(dòng)子區(qū)域的結(jié)合、轉(zhuǎn)錄復(fù)合物的組裝及基因表達(dá)。

Features and Benefits

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該化合物由Eisai開(kāi)發(fā)。

5-Aza-2′-deoxycytidine is a DNA-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.[1] It is a 2′-deoxycytidine analogue.[2] 5-Aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.